abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

journal_title：Journal of endocrinological investigation

authors： Warren MP,Goodman LR

更新日期：2003-09-01 00:00:00

abstract：:Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...

journal_title：Journal of endocrinological investigation

authors： Zadik Z

更新日期：2003-09-01 00:00:00

abstract：:Cortistatin (CST), a 17-amino acid peptide partially homologous to somatostatin (SRIF), has been originally isolated from the cerebral cortex and recently found in monocytes and macrophages of the immune system. CST binds all 5 SRIF receptors, as well the GH secretagogue (GHS)/ghrelin receptors. CST exerts sleep promo...

journal_title：Journal of endocrinological investigation

authors： Papotti M,Tarabra E,Allia E,Bozzalla-Cassione F,Broglio F,Deghenghi R,Ghigo E,Muccioli G

更新日期：2003-08-01 00:00:00

abstract：:In vitro studies have shown that 1,25 dihydroxyvitamin D3 [1,25(OH)2D3] decreases cytokine production by monocytes and lymphocytes. In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients. We studied the effect of a daily 12-wee...

journal_title：Journal of endocrinological investigation

authors： Gannagé-Yared MH,Azoury M,Mansour I,Baddoura R,Halaby G,Naaman R

更新日期：2003-08-01 00:00:00

abstract：:An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordi...

journal_title：Journal of endocrinological investigation

authors： Wallerius S,Rosmond R,Ljung T,Holm G,Björntorp P

更新日期：2003-07-01 00:00:00

abstract：:Adrenal origin and ACTH-dependent secretion of endogenous digitalis-like factor(s) (EDLF) was investigated. Twelve normal weight normotensive subjects (normal group) and 10 patients with Addison's disease (Addison group) were subjected to prolonged ACTH stimulation with 1 mg tetracosactin-depot im. Blood sampling was ...

journal_title：Journal of endocrinological investigation

authors： Sophocleous A,Elmatzoglou I,Souvatzoglou A

更新日期：2003-07-01 00:00:00

abstract：:To investigate the impact of obstructive sleep apnea syndrome (OSAS) on testosterone levels and on the main parameters of the metabolic syndrome in abdominally obese men, 15 male subjects with abdominal obesity phenotype and polysomnographic diagnosis of OSAS (OB-OSAS) and 15 controls matched for age and anthropometri...

journal_title：Journal of endocrinological investigation

authors： Gambineri A,Pelusi C,Pasquali R

更新日期：2003-06-01 00:00:00

abstract：:A 71-yr-old man was admitted for further evaluation and trans-sphenoidal surgery of a pituitary tumor. He complained of impotence and decreased libido over a period of about 40 yr. Thirty-eight yr ago he was treated for bilateral gynecomastia with galactorrhea. Endocrinological investigation at presentation revealed o...

journal_title：Journal of endocrinological investigation

authors： Wiesli P,Brändle M,Brandner S,Kollias SS,Bernays RL

更新日期：2003-06-01 00:00:00

abstract：:The effect of right- and left-sided intra-amygdaloid injection of kainic acid on the hypothalamo-hypophyseal-testicular axis was studied in rats. Both right- and left-sided injection of the neurotoxin into the amygdala resulted in a significant decrease in basal testosterone secretion in vitro of both testes and in se...

journal_title：Journal of endocrinological investigation

authors： Banczerowski P,Csaba Z,Csernus V,Gerendai I

更新日期：2003-05-01 00:00:00

abstract：:We evaluated the oral calcium-loading test (OCLT) in diagnosing normocalcemic primary hyperparathyroidism. Calcium and PTH levels were measured before, 60, 120 and 180 min after oral 1 g of calcium gluconolactate administration in 102 consecutive females with high circulating PTH levels, and 25 controls. Patients were...

journal_title：Journal of endocrinological investigation

authors： Hagag P,Revet-Zak I,Hod N,Horne T,Rapoport MJ,Weiss M

更新日期：2003-04-01 00:00:00

abstract：:The pineal gland contains many peptides known to be implicated in melatonin production. We examined the effects of a synthetic pineal tetrapeptide Ala-Glu-Asp-Gly on melatonin secretion by the pineal gland. The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months)...

journal_title：Journal of endocrinological investigation

authors： Djeridane Y,Khavinson VKh,Anisimov VN,Touitou Y

更新日期：2003-03-01 00:00:00

abstract：:Disulfide bonds are formed between the sulfhydryl groups in two cysteine residues of a protein. The formation of these bonds is necessary for the proper folding of a protein into its active three-dimensional form. In this study, the genes associated with disulfide bond formation of proteins from the rat thyroid cell l...

journal_title：Journal of endocrinological investigation

authors： Park S,Hwang I,Shong M,Kwon OY

更新日期：2003-02-01 00:00:00

abstract：:Pegvisomant, a GH receptor antagonist, is a new pharmaceutical approach to acromegaly. It enables IGF-I levels to return in the age- and sex-reference range in approximately 90% of patients. This new approach is particularly beneficial in those patients who do not experience control of hormone hypersecretion after sur...

journal_title：Journal of endocrinological investigation

authors： Colao A,Pivonello R,Cappabianca P,Auriemma RS,De Martino MC,Ciccarelli A,de Divitiis E,Lombardi G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:In the mountainous areas of Azerbaijan the schoolchildren suffer from severe Iodine Deficiency (ID) with median Urinary iodine excretion (UIE) 36 mcg/l and prevalence of goiter 99% (estimated by US). In a population of 293,000 schoolchildren aged 8-14 y.o. we administered capsules containing 190 mg of iodized...

journal_title：Journal of endocrinological investigation

authors： Markou KB,Georgopoulos NA,Makri M,Vlasopoulou B,Anastasiou E,Vagenakis GA,Kouloubi K,Theodosopoulos N,Lazarou N,Veizis A,Sakellaropoulos G,Vagenakis AG

更新日期：2003-01-01 00:00:00

abstract：:Differently from other metabolic conditions, most of calcium metabolism disorders are diagnosed through simple detection of both serum and urinary excretion (24-h urine collection), levels of calcium, total and ionized form, and phosphate, and of calciotropic hormone serum levels, such as calcitonin, PTH and vitamin D...

journal_title：Journal of endocrinological investigation

authors： Cioppi F,Falchetti A,Masi L,Brandi ML

更新日期：2003-01-01 00:00:00

abstract：:Microvessel density (MVD) represents a measure of angiogenesis and may be used as an indicator of neoplastic aggressiveness. Vascular endothelial growth factor (VEGF) plays a pivotal role as angiogenic promoter by stimulating endothelial cell proliferation and migration and enhancing vascular permeability. The aim of ...

journal_title：Journal of endocrinological investigation

authors： Viacava P,Gasperi M,Acerbi G,Manetti L,Cecconi E,Bonadio AG,Naccarato AG,Acerbi F,Parenti G,Lupi I,Genovesi M,Martino E

更新日期：2003-01-01 00:00:00

abstract：:The case of a 15-yr-old boy with C11 hydroxylase deficiency congenital adrenal hyperplasia is reported who was diagnosed and treated as true precocious puberty at the age of 2 yr because of virilization and bilateral testicular enlargement. He later developed hyperpigmentation, hypertension and short stature and becau...

journal_title：Journal of endocrinological investigation

authors： Ghazi AA,Hadayegh F,Khakpour G,Azizi F,Melby JC

更新日期：2003-01-01 00:00:00

abstract：:The last decade has witnessed an upsurge of interest in the research on facial attractiveness. The development of computer graphics has allowed to objectively investigate the conserved features of attractive faces. Averageness, symmetry and sex-specific traits have been associated with attractiveness. The effect of av...

journal_title：Journal of endocrinological investigation

authors： Cellerino A

更新日期：2003-01-01 00:00:00

abstract：:Anatomy studies normally precede physiology. While the anatomy of the penis and the biochemical and molecular regulation of erection are largely known, the exact anatomical description of the human clitoris was produced in 1998, the taxonomy of female sexual dysfunctions classified in 1999, and biochemistry of female ...

journal_title：Journal of endocrinological investigation

authors： D'Amati G,di Gioia CR,Proietti Pannunzi L,Pistilli D,Carosa E,Lenzi A,Jannini EA

更新日期：2003-01-01 00:00:00

abstract：:The recent development of new medications for the treatment of the sexual dysfunction increased the possibility of improving the altered sexual performance. Although initially designed for the treatment of male sexual dysfunction, erectile dysfunction in particular, these substances have now been tested for the therap...

journal_title：Journal of endocrinological investigation

authors： Spera G,Pili M,Gnessi L,Spera E,Mariani S

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of age, duration of diabetes, sex and ICA (Islet cell cytoplasmic antibody) on beta-cell reserves and to develop a model within the first 2 years of Type 1 diabetes. Beta-cell reserve is evaluated as fasting (FCp) and 1 mg i.v. glucagon stimulated C-peptide (SCp) le...

journal_title：Journal of endocrinological investigation

authors： Altuntas Y

更新日期：2002-12-01 00:00:00

abstract：:Many studies have shown that fat distribution influences metabolism independently of the effects of total body fat stores. The accumulation of fat in the abdominal area, particularly in the visceral fat compartment, seems to be associated with an increased risk to display complications such as insulin resistance, diab...

journal_title：Journal of endocrinological investigation

authors： Gasteyger C,Tremblay A

更新日期：2002-11-01 00:00:00

abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, but well-defined monogenic disorder that is caused by mutations in the autoimmune regulator (AIRE) gene on chromosome 21q22.3. Patients most often suffer from loss of endocrine function in the parathyroid and adrenal glands but may also...

journal_title：Journal of endocrinological investigation

authors： Meyer G,Badenhoop K

更新日期：2002-10-01 00:00:00

abstract：:The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding prote...

journal_title：Journal of endocrinological investigation

authors： Legan M,Kocijancic A,Prezelj J,Osredkar J,Fisker S

更新日期：2002-09-01 00:00:00

abstract：:EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men s...

journal_title：Journal of endocrinological investigation

authors： Broglio F,Boutignon F,Benso A,Gottero C,Prodam F,Arvat E,Ghè C,Catapano F,Torsello A,Locatelli V,Muccioli G,Boeglin D,Guerlavais V,Fehrentz JA,Martinez J,Ghigo E,Deghenghi R

更新日期：2002-09-01 00:00:00

abstract：:E-cadherin and catenins play a major role in neoplastic cell behavior as a suppressor of invasion and/or metastasis. The aim of this study was to determine E-cadherin, alpha-catenin and beta-catenin expressions in papillary thyroid carcinoma (PTC) and to correlate the results of expression to initial clinicopathologic...

journal_title：Journal of endocrinological investigation

authors： Kapran Y,Ozbey N,Molvalilar S,Sencer E,Dizdaroğlu F,Ozarmağan S

更新日期：2002-07-01 00:00:00

abstract：:17alpha-hydroxylase deficiency (17alpha-OHDS) results in decreased production of cortisol and sex steroids and hypokalemia secondary to excess mineralocorticoids. It has long been known that glucocorticoid deficiency is associated with impaired urinary dilution and increased secretion of vasopressin (AVP). On the othe...

journal_title：Journal of endocrinological investigation

authors： Leal AM,Elias PC,Moreira AC

更新日期：2002-07-01 00:00:00

abstract：:Impaired glucose tolerance is present in many acromegalic patients and treatment with somatostatin analogs has variable effects on glycemic control. The aim of this study was to compare the effects of 2 somatostatin analogs on glucose metabolism, lanreotide slow release (L-SR) and octreotide long acting release (O-LAR...

journal_title：Journal of endocrinological investigation

authors： Ronchi C,Epaminonda P,Cappiello V,Beck-Peccoz P,Arosio M

更新日期：2002-06-01 00:00:00

abstract：:Hypocalcemia associated with labor and lactation is a rare condition reported previously in patients with hypovitaminosis D. We here describe a case of a young woman in whom symptomatic severe hypocalcemia appeared after her second delivery, early in lactation. At the end of lactation the condition worsened. We review...

journal_title：Journal of endocrinological investigation

authors： Durst R,Meirovitz A,Gross D,Kolker O,Muszkat M

更新日期：2002-06-01 00:00:00

abstract：:The type of dietary fat affects the action of insulin by changes induced in the fatty acid composition of cell membranes. Little is known, however, about the effects of dietary fatty acids on insulin secretion or the possible relation between the fatty acid composition of the membrane phospholipids and insulin secreti...

journal_title：Journal of endocrinological investigation

authors： Tinahones FJ,Pareja A,Soriguer FJ,Gómez-Zumaquero JM,Cardona F,Rojo-Martínez G

更新日期：2002-05-01 00:00:00

abstract：:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and red...

journal_title：Journal of endocrinological investigation

authors： Bellone S,Rapa A,Vivenza D,Castellino N,Petri A,Bellone J,Me E,Broglio F,Prodam F,Ghigo E,Bona G

更新日期：2002-05-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) plays a well-recognized role in the regulation of BP and in salt and water balance. Since hypertension affects a considerable proportion of obese patients, circulating RAAS has been studied in obese subjects with and without hypertension, albeit with conflicting results....

journal_title：Journal of endocrinological investigation

authors： Faloia E,Gatti C,Camilloni MA,Mariniello B,Sardu C,Garrapa GG,Mantero F,Giacchetti G

更新日期：2002-04-01 00:00:00

abstract：:Several cases of ovarian neoplasms resulting in Cushing's syndrome due to ectopic secretion of ACTH or ectopic secretion of F have been reported. Tumors producing ACTH include adenocarcinoma, androblastoma, Sertoli cell carcinoma, carcinoid tumor and teratoma. Cortisol secretion has been reported in ovarian steroid ce...

journal_title：Journal of endocrinological investigation

authors： Sworczak K,Blaut K,Malecha M,Lewczuk A

更新日期：2002-04-01 00:00:00

abstract：:The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data we...

journal_title：Journal of endocrinological investigation

authors： Costante G,Grasso L,Schifino E,Marasco MF,Crocetti U,Capula C,Chiarella R,Ludovico O,Nocera M,Parlato G,Filetti S

更新日期：2002-03-01 00:00:00

abstract：:Molecular diagnostics of the LHR gene was conducted in a 5-year-old boy with clinical symptoms and hormonal profile typical of precocious puberty. His parents and 4 sisters were also diagnosed. Single-strand conformation polymorphism analysis under temperature gradient conditions (Multitemperature SSCP) of 3 overlappi...

journal_title：Journal of endocrinological investigation

authors： Ignacak M,Starzyk J,Dziatkowiak H,Trzeciak WH

更新日期：2002-03-01 00:00:00

abstract：:Serial weekly serum samples (for 3 weeks) were obtained from 42 patients with differentiated thyroid cancer (DTC, papillary no.=35, follicular no.=6, Hurthle cell no.=1) for serum thyroid hormone, TSH and TG before and after total thyroidectomy. Serum specimens were also obtained one month after radioiodine (131I) the...

journal_title：Journal of endocrinological investigation

authors： Lima N,Cavaliere H,Tomimori E,Knobel M,Medeiros-Neto G

更新日期：2002-02-01 00:00:00

abstract：:Multiple pituitary hormone hypersecretions have already been described, but the co-occurrence of PRL and ACTH excess is very rare. To our knowledge, medical treatment with cabergoline only, avoiding pituitary surgery and radiotherapy in this type of tumor has never been reported before. This case report deals with a 3...

journal_title：Journal of endocrinological investigation

authors： T'Sjoen G,Defeyter I,Van De Saffele J,Rubens R,Vandeweghe M

更新日期：2002-02-01 00:00:00

abstract：:Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...

journal_title：Journal of endocrinological investigation

authors： Valenti G

更新日期：2002-01-01 00:00:00

abstract：:Many hirsute women may present a form of functional ovarian hyperandrogenism (FOH), since they show an exaggerated 17-hydroxyprogesterone (17-OHP) response to GnRH agonists administration. As the failure of dexamethasone to reduce testosterone levels may be indicative of an ovarian source of androgen secretion, we eva...

journal_title：Journal of endocrinological investigation

authors： Re T,Barbetta L,Dall'Asta C,Faglia G,Ambrosi B

更新日期：2002-01-01 00:00:00

abstract：:Forty-eight morbidly obese patients were placed on a very low calorie (800 kcal) formula diet (OPTIFAST) for a 10-week period with the goal of achieving 10% weight loss within this time. Weekly serum leptin measurements were performed to determine whether changes in this adipose protein would serve as a useful marker ...

journal_title：Journal of endocrinological investigation

authors： Xenachis C,Samojlik E,Raghuwanshi MP,Kirschner MA

更新日期：2001-12-01 00:00:00